[HTML][HTML] Zinc inhibition of mitochondrial aconitase and its importance in citrate metabolism of prostate epithelial cells
LC Costello, Y Liu, RB Franklin, MC Kennedy - Journal of Biological …, 1997 - ASBMB
Prostate epithelial cells possess a uniquely limiting mitochondrial (m-) aconitase activity that
minimizes their ability to oxidize citrate. These cells also possess uniquely high cellular and
mitochondrial zinc levels. Correlations among zinc, citrate, and m-aconitase in prostate
indicated that zinc might be an inhibitor of prostate m-aconitase activity and citrate oxidation.
The present studies reveal that zinc at near physiological levels inhibited m-aconitase
activity of mitochondrial sonicate preparations obtained from rat ventral prostate epithelial …
minimizes their ability to oxidize citrate. These cells also possess uniquely high cellular and
mitochondrial zinc levels. Correlations among zinc, citrate, and m-aconitase in prostate
indicated that zinc might be an inhibitor of prostate m-aconitase activity and citrate oxidation.
The present studies reveal that zinc at near physiological levels inhibited m-aconitase
activity of mitochondrial sonicate preparations obtained from rat ventral prostate epithelial …