[PDF][PDF] Cellular fatty acid metabolism and cancer

E Currie, A Schulze, R Zechner, TC Walther, RV Farese - Cell metabolism, 2013 - cell.com
Cell metabolism, 2013cell.com
Cancer cells often have characteristic changes in metabolism. Cellular proliferation, a
common feature of all cancers, requires fatty acids for synthesis of membranes and signaling
molecules. Here, we provide a view of cancer cell metabolism from a lipid perspective, and
we summarize evidence that limiting fatty acid availability can control cancer cell
proliferation.
Cancer cells often have characteristic changes in metabolism. Cellular proliferation, a common feature of all cancers, requires fatty acids for synthesis of membranes and signaling molecules. Here, we provide a view of cancer cell metabolism from a lipid perspective, and we summarize evidence that limiting fatty acid availability can control cancer cell proliferation.
cell.com