Hydrolyzed infant formula and early β-cell autoimmunity: a randomized clinical trial
M Knip, HK Åkerblom, D Becker, HM Dosch, J Dupre… - Jama, 2014 - jamanetwork.com
Importance The disease process leading to clinical type 1 diabetes often starts during the
first years of life. Early exposure to complex dietary proteins may increase the risk of β-cell
autoimmunity in children at genetic risk for type 1 diabetes. Extensively hydrolyzed formulas
do not contain intact proteins. Objective To test the hypothesis that weaning to an
extensively hydrolyzed formula decreases the cumulative incidence of diabetes-associated
autoantibodies in young children. Design, Setting, and Participants A double-blind …
first years of life. Early exposure to complex dietary proteins may increase the risk of β-cell
autoimmunity in children at genetic risk for type 1 diabetes. Extensively hydrolyzed formulas
do not contain intact proteins. Objective To test the hypothesis that weaning to an
extensively hydrolyzed formula decreases the cumulative incidence of diabetes-associated
autoantibodies in young children. Design, Setting, and Participants A double-blind …