Cells respond to genotoxic insults by triggering a DNA damage checkpoint surveillance
mechanism and by activating repair pathways. Recent findings indicate that the two
processes are more related than originally thought. Here we discuss the mechanisms
involved in responding to UV-induced lesions in different phases of the cell cycle and
summarize the most recent data in a model where Nucleotide Excision Repair (NER) and
exonucleolytic activities act in sequence leading to checkpoint activation in non replicating …