Chronic CXCL10 alters neuronal properties in rat hippocampal culture
J Cho, TE Nelson, H Bajova, DL Gruol - Journal of neuroimmunology, 2009 - Elsevier
The chemokine CXCL10 is expressed in the central nervous system (CNS) during
neuroinflammatory conditions. Neurons express CXCR3, the receptor for CXCL10, and
neuronal function has been shown to be altered by acute exposure to CXCL10. Little is
known about the effects of chronic exposure to CXCL10 on neuronal function. Results from
our studies show that chronic exposure of cultured rat hippocampal neurons to CXCL10
results in altered levels of protein for GABA and glutamate receptors and altered synaptic …
neuroinflammatory conditions. Neurons express CXCR3, the receptor for CXCL10, and
neuronal function has been shown to be altered by acute exposure to CXCL10. Little is
known about the effects of chronic exposure to CXCL10 on neuronal function. Results from
our studies show that chronic exposure of cultured rat hippocampal neurons to CXCL10
results in altered levels of protein for GABA and glutamate receptors and altered synaptic …