[HTML][HTML] Group VIA phospholipase A2 (iPLA2β) participates in angiotensin II-induced transcriptional up-regulation of regulator of G-protein signaling-2 in vascular …
Rgs2 (regulator of G-protein signaling-2)-deficient mice exhibit severe hypertension, and
genetic variations of RGS2 occur in hypertensive patients. RGS2 mRNA up-regulation by
angiotensin II (Ang II) in vascular smooth muscle cells (VSMC) is a potentially important
negative feedback mechanism in blood pressure homeostasis, but how it occurs is
unknown. Here we demonstrate that group VIA phospholipase A 2 (iPLA 2 β) plays a pivotal
role in Ang II-induced RGS2 mRNA up-regulation in VSMC by three independent …
genetic variations of RGS2 occur in hypertensive patients. RGS2 mRNA up-regulation by
angiotensin II (Ang II) in vascular smooth muscle cells (VSMC) is a potentially important
negative feedback mechanism in blood pressure homeostasis, but how it occurs is
unknown. Here we demonstrate that group VIA phospholipase A 2 (iPLA 2 β) plays a pivotal
role in Ang II-induced RGS2 mRNA up-regulation in VSMC by three independent …