Expression of IL-33 in the epidermis: The mechanism of induction by IL-17
J Meephansan, M Komine, H Tsuda… - Journal of …, 2013 - Elsevier
Abstract Background Interleukin (IL)-33 is a dual functional, IL-1 family member cytokine,
whose exact roles in inflammatory skin diseases are still unknown. IL-17A is a key cytokine
in the pathogenesis of psoriasis. Objectives We investigated if IL-17A could induce IL-33 in
epidermal keratinocytes, and the signaling mechanisms involved. Methods IL-33 levels were
evaluated by RT-PCR and western blot in human keratinocytes following IL-17A simulation.
IL-33 immunohistochemical staining of psoriatic skin samples was also performed and …
whose exact roles in inflammatory skin diseases are still unknown. IL-17A is a key cytokine
in the pathogenesis of psoriasis. Objectives We investigated if IL-17A could induce IL-33 in
epidermal keratinocytes, and the signaling mechanisms involved. Methods IL-33 levels were
evaluated by RT-PCR and western blot in human keratinocytes following IL-17A simulation.
IL-33 immunohistochemical staining of psoriatic skin samples was also performed and …