Inhibitors of histone deacetylase (HDAC) have anti-inflammatory and antifibrotic effects in
several organs and tissues, but their effect on the progression of renal disease is unknown.
Here, we studied the effect of valproic acid in adriamycin-induced nephropathy in mice.
Administration of valproic acid before kidney injury prevented the development of proteinuria
and the onset of glomerulosclerosis. Even after postponing treatment until the peak of
adriamycin-induced proteinuria, valproic acid rapidly decreased the quantity of proteinuria …