Differential roles of glycogen synthase kinase-3 isoforms in the regulation of transcriptional activation
MH Liang, DM Chuang - Journal of Biological Chemistry, 2006 - ASBMB
Glycogen synthase kinase-3 (GSK-3) exists as two structurally similar isoforms, α and β,
whose activities are negatively regulated by serine phosphorylation but positively controlled
by tyrosine phosphorylation. We used GSK-3 isoform-specific small interfering RNAs,
dominant negative mutants, and pharmacological inhibitors to search for the differential
roles for both GSK-3 isoforms in regulating transcriptional activation in cultured rat cerebral
cortical neurons. GSK-3α and GSK-3β were shown to have differentially regulated …
whose activities are negatively regulated by serine phosphorylation but positively controlled
by tyrosine phosphorylation. We used GSK-3 isoform-specific small interfering RNAs,
dominant negative mutants, and pharmacological inhibitors to search for the differential
roles for both GSK-3 isoforms in regulating transcriptional activation in cultured rat cerebral
cortical neurons. GSK-3α and GSK-3β were shown to have differentially regulated …
