Tubular p53 regulates multiple genes to mediate AKI
A pathogenic role of p53 in AKI was suggested a decade ago but remains controversial.
Indeed, recent work indicates that inhibition of p53 protects against ischemic AKI in rats but
exacerbates AKI in mice. One intriguing possibility is that p53 has cell type-specific roles in
AKI. To determine the role of tubular p53, we generated two conditional gene knockout
mouse models, in which p53 is specifically ablated from proximal tubules or other tubular
segments, including distal tubules, loops of Henle, and medullary collecting ducts. Proximal …
Indeed, recent work indicates that inhibition of p53 protects against ischemic AKI in rats but
exacerbates AKI in mice. One intriguing possibility is that p53 has cell type-specific roles in
AKI. To determine the role of tubular p53, we generated two conditional gene knockout
mouse models, in which p53 is specifically ablated from proximal tubules or other tubular
segments, including distal tubules, loops of Henle, and medullary collecting ducts. Proximal …
