Impairments in certain cognitive functions mediated by the dorsolateral prefrontal cortex,
such as working memory, are core features of schizophrenia. Convergent findings suggest
that these disturbances are associated with alterations in markers of inhibitory γ-
aminobutyric acid and excitatory glutamate neurotransmission in the dorsolateral prefrontal
cortex. Specifically, reduced γ-aminobutyric acid synthesis is present in the subpopulation of
γ-aminobutyric acid neurons that express the calcium-binding protein parvalbumin. Despite …