Systemic antigen cross-presented by liver sinusoidal endothelial cells induces liver-specific CD8 T-cell retention and tolerization
N Von Oppen, A Schurich, S Hegenbarth… - Hepatology, 2009 - journals.lww.com
Peripheral CD8 T-cell tolerance can be generated outside lymphatic tissue in the liver, but
the course of events leading to tolerogenic interaction of hepatic cell populations with
circulating T-cells remain largely undefined. Here we demonstrate that preferential uptake of
systemically circulating antigen by murine liver sinusoidal endothelial cells (LSECs), and not
by other antigen-presenting cells in the liver or spleen, leads to cross-presentation on major
histocompatibility complex (MHC) I molecules, which causes rapid antigen-specific naïve …
the course of events leading to tolerogenic interaction of hepatic cell populations with
circulating T-cells remain largely undefined. Here we demonstrate that preferential uptake of
systemically circulating antigen by murine liver sinusoidal endothelial cells (LSECs), and not
by other antigen-presenting cells in the liver or spleen, leads to cross-presentation on major
histocompatibility complex (MHC) I molecules, which causes rapid antigen-specific naïve …