[HTML][HTML] Metformin activates AMP kinase through inhibition of AMP deaminase
J Ouyang, RA Parakhia, RS Ochs - Journal of Biological Chemistry, 2011 - ASBMB
The mechanism for how metformin activates AMPK (AMP-activated kinase) was investigated
in isolated skeletal muscle L6 cells. A widely held notion is that inhibition of the
mitochondrial respiratory chain is central to the mechanism. We also considered other
proposals for metformin action. As metabolic pathway markers, we focused on glucose
transport and fatty acid oxidation. We also confirmed metformin actions on other metabolic
processes in L6 cells. Metformin stimulated both glucose transport and fatty acid oxidation …
in isolated skeletal muscle L6 cells. A widely held notion is that inhibition of the
mitochondrial respiratory chain is central to the mechanism. We also considered other
proposals for metformin action. As metabolic pathway markers, we focused on glucose
transport and fatty acid oxidation. We also confirmed metformin actions on other metabolic
processes in L6 cells. Metformin stimulated both glucose transport and fatty acid oxidation …
