[PDF][PDF] Targeting oxidative phosphorylation: why, when, and how
M Pollak - Cancer cell, 2013 - cell.com
Cancer cell, 2013•cell.com
In this issue of Cancer Cell, Vazquez and colleagues report reduced glycolysis and
increased oxidative phosphorylation in certain melanomas, revealing metabolic plasticity
rather than stable Warburg pathophysiology. Furthermore, Haq and colleagues (also in this
issue of Cancer Cell) show situations where increased oxidative phosphorylation is required
for melanomas to survive inhibition of B-RAF, suggesting investigation of therapeutic
combinations of B-RAF inhibitors with biguanides.
increased oxidative phosphorylation in certain melanomas, revealing metabolic plasticity
rather than stable Warburg pathophysiology. Furthermore, Haq and colleagues (also in this
issue of Cancer Cell) show situations where increased oxidative phosphorylation is required
for melanomas to survive inhibition of B-RAF, suggesting investigation of therapeutic
combinations of B-RAF inhibitors with biguanides.
In this issue of Cancer Cell, Vazquez and colleagues report reduced glycolysis and increased oxidative phosphorylation in certain melanomas, revealing metabolic plasticity rather than stable Warburg pathophysiology. Furthermore, Haq and colleagues (also in this issue of Cancer Cell) show situations where increased oxidative phosphorylation is required for melanomas to survive inhibition of B-RAF, suggesting investigation of therapeutic combinations of B-RAF inhibitors with biguanides.
cell.com
