Increasing expression of monocarboxylate transporters 1 and 4 along progression to invasive cervical carcinoma
C Pinheiro, A Longatto-Filho, L Ferreira… - International journal …, 2008 - journals.lww.com
Solid tumor cells are known to be highly glycolytic and, to prevent apoptosis by cellular
acidosis, cells increase proton efflux through pH regulators, such as monocarboxylate
transporters (MCTs). However, the role of these membrane proteins in solid tumor
development and survival is not fully understood. We aimed to evaluate the expression of
the MCT isoforms 1, 2, and 4 in a large series of cervical lesions (neoplastic and non-
neoplastic) and assess its clinical-pathologic significance. The series analyzed included 29 …
acidosis, cells increase proton efflux through pH regulators, such as monocarboxylate
transporters (MCTs). However, the role of these membrane proteins in solid tumor
development and survival is not fully understood. We aimed to evaluate the expression of
the MCT isoforms 1, 2, and 4 in a large series of cervical lesions (neoplastic and non-
neoplastic) and assess its clinical-pathologic significance. The series analyzed included 29 …
