Inhibition of tumor lactate oxidation: consequences for the tumor microenvironment
M Busk, S Walenta, W Mueller-Klieser… - Radiotherapy and …, 2011 - Elsevier
BACKGROUND AND PURPOSE: Tumor cells are recognized as being highly glycolytic.
However, recently it was suggested that lactate produced in hypoxic tumor areas may be
taken up by the monocarboxylate transporter MCT1 and oxidized in well-oxygenated tumor
parts. Furthermore, it was shown that inhibition of lactate oxidation using the MCT1 inhibitor
α-cyano-hydroxycinnamate (CHC) can radio-sensitize tumors possibly by forcing a switch
from lactate oxidization to glycolysis in oxygenated cells, which in turn improves tumor …
However, recently it was suggested that lactate produced in hypoxic tumor areas may be
taken up by the monocarboxylate transporter MCT1 and oxidized in well-oxygenated tumor
parts. Furthermore, it was shown that inhibition of lactate oxidation using the MCT1 inhibitor
α-cyano-hydroxycinnamate (CHC) can radio-sensitize tumors possibly by forcing a switch
from lactate oxidization to glycolysis in oxygenated cells, which in turn improves tumor …
