[HTML][HTML] Succination of protein thiols during adipocyte maturation
R Nagai, JW Brock, M Blatnik, JE Baatz… - Journal of biological …, 2007 - ASBMB
Although obesity is a risk factor for development of type 2 diabetes and chemical
modification of proteins by advanced glycoxidation and lipoxidation end products is
implicated in the development of diabetic complications, little is known about the chemical
modification of proteins in adipocytes or adipose tissue. In this study we show that S-(2-
succinyl) cysteine (2SC), the product of chemical modification of proteins by the Krebs cycle
intermediate, fumarate, is significantly increased during maturation of 3T3-L1 fibroblasts to …
modification of proteins by advanced glycoxidation and lipoxidation end products is
implicated in the development of diabetic complications, little is known about the chemical
modification of proteins in adipocytes or adipose tissue. In this study we show that S-(2-
succinyl) cysteine (2SC), the product of chemical modification of proteins by the Krebs cycle
intermediate, fumarate, is significantly increased during maturation of 3T3-L1 fibroblasts to …