[HTML][HTML] The progression of aging in klotho mutant mice can be modified by dietary phosphorus and zinc
K Morishita, M Kubota, Y Katakura, T Kamiya… - The Journal of …, 2001 - Elsevier
Reduction in klotho gene expression causes accelerated senescence in klotho mutant mice.
We have now found two key substances, phosphorus and zinc, which affect the appearance
of klotho phenotypes. Klotho mutant homozygotes fed nonpurified diet with a phosphorus
concentration of 1.03 g/100 g showed typical klotho phenotypes. However, most of the
klotho phenotypes no longer appeared in male homozygotes fed a 0.4 g/100 g phosphorus
diet. These homozygotes were capable of spermatogenesis. In the kidneys of the rescued …
We have now found two key substances, phosphorus and zinc, which affect the appearance
of klotho phenotypes. Klotho mutant homozygotes fed nonpurified diet with a phosphorus
concentration of 1.03 g/100 g showed typical klotho phenotypes. However, most of the
klotho phenotypes no longer appeared in male homozygotes fed a 0.4 g/100 g phosphorus
diet. These homozygotes were capable of spermatogenesis. In the kidneys of the rescued …