In vivo 13C NMR spectroscopy and metabolic modeling in the brain: a practical perspective
In vivo 13C NMR spectroscopy has the unique capability to measure metabolic fluxes
noninvasively in the brain. Quantitative measurements of metabolic fluxes require analysis
of the 13C labeling time courses obtained experimentally with a metabolic model. The
present work reviews the ingredients necessary for a dynamic metabolic modeling study,
with particular emphasis on practical issues.
noninvasively in the brain. Quantitative measurements of metabolic fluxes require analysis
of the 13C labeling time courses obtained experimentally with a metabolic model. The
present work reviews the ingredients necessary for a dynamic metabolic modeling study,
with particular emphasis on practical issues.
