Cytokine milieu modulates release of thymic stromal lymphopoietin from human keratinocytes stimulated with double-stranded RNA
H Kinoshita, T Takai, TA Le, S Kamijo, XL Wang… - Journal of allergy and …, 2009 - Elsevier
BACKGROUND: Thymic stromal lymphopoietin (TSLP) plays a key role in allergic diseases,
such as atopic dermatitis (AD) and asthma. TSLP is highly expressed by keratinocytes in
skin lesions of patients with AD, but environmental triggers for its release from keratinocytes
with endogenous factors are not well understood. Patients with AD, in whom allergic
sensitization is already established, are susceptible to viral dissemination. OBJECTIVES:
We investigated TSLP's release from primary human keratinocytes stimulated with a Toll-like …
such as atopic dermatitis (AD) and asthma. TSLP is highly expressed by keratinocytes in
skin lesions of patients with AD, but environmental triggers for its release from keratinocytes
with endogenous factors are not well understood. Patients with AD, in whom allergic
sensitization is already established, are susceptible to viral dissemination. OBJECTIVES:
We investigated TSLP's release from primary human keratinocytes stimulated with a Toll-like …
