Incorporation of tenascin-C into the extracellular matrix by periostin underlies an extracellular meshwork architecture
I Kii, T Nishiyama, M Li, K Matsumoto, M Saito… - Journal of Biological …, 2010 - ASBMB
Extracellular matrix (ECM) underlies a complicated multicellular architecture that is
subjected to significant forces from mechanical environment. Although various components
of the ECM have been enumerated, mechanisms that evolve the sophisticated ECM
architecture remain to be addressed. Here we show that periostin, a matricellular protein,
promotes incorporation of tenascin-C into the ECM and organizes a meshwork architecture
of the ECM. We found that both periostin null mice and tenascin-C null mice exhibited a …
subjected to significant forces from mechanical environment. Although various components
of the ECM have been enumerated, mechanisms that evolve the sophisticated ECM
architecture remain to be addressed. Here we show that periostin, a matricellular protein,
promotes incorporation of tenascin-C into the ECM and organizes a meshwork architecture
of the ECM. We found that both periostin null mice and tenascin-C null mice exhibited a …
