[HTML][HTML] Inhibition of interleukin-12 p40 transcription and NF-κB activation by nitric oxide in murine macrophages and dendritic cells
H Xiong, C Zhu, F Li, R Hegazi, K He… - Journal of Biological …, 2004 - ASBMB
Nitric oxide (NO), an important effector molecule of the innate immune system, can also
regulate adaptive immunity. In this study, the molecular effects of NO on the toll-like receptor
signaling pathway were determined using interleukin-12 (IL-12) as an immunologically
relevant target gene. The principal conclusion of these experiments is that NO inhibits IL-1
receptor-associated kinase (IRAK) activity and attenuates the molecular interaction between
tumor necrosis factor receptor-associated factor-6 and IRAK. As a consequence, the NO …
regulate adaptive immunity. In this study, the molecular effects of NO on the toll-like receptor
signaling pathway were determined using interleukin-12 (IL-12) as an immunologically
relevant target gene. The principal conclusion of these experiments is that NO inhibits IL-1
receptor-associated kinase (IRAK) activity and attenuates the molecular interaction between
tumor necrosis factor receptor-associated factor-6 and IRAK. As a consequence, the NO …