Involvement of sirtuin 1 in airway inflammation and hyperresponsiveness of allergic airway disease
SR Kim, KS Lee, SJ Park, KH Min, YH Choe… - Journal of Allergy and …, 2010 - Elsevier
BACKGROUND: Bronchial asthma is a chronic inflammatory disorder of the airways
characterized by increased expression of multiple inflammatory genes. Acetylation of
histones by histone acetyltransferases is associated with increased gene transcription,
whereas hypoacetylation induced by histone deacetylases is associated with suppression of
gene expression. Sirtuin 1 (SIRT1) is a member of the silent information regulator 2 family
that belongs to class III histone deacetylase. OBJECTIVE: This study aimed to investigate the …
characterized by increased expression of multiple inflammatory genes. Acetylation of
histones by histone acetyltransferases is associated with increased gene transcription,
whereas hypoacetylation induced by histone deacetylases is associated with suppression of
gene expression. Sirtuin 1 (SIRT1) is a member of the silent information regulator 2 family
that belongs to class III histone deacetylase. OBJECTIVE: This study aimed to investigate the …