Transcriptional regulatory mechanisms of cardiac oxidative stress resistance are not well
defined. FoxO transcription factors are critical mediators of oxidative stress resistance in
multiple cell types, but cardioprotective functions have not been reported previously. FoxO
function in oxidative stress resistance was investigated in cultured cardiomyocytes and in
mice with cardiomyocyte-specific combined deficiency of FoxO1 and FoxO3 subjected to
myocardial infarction (MI) or acute ischemia/reperfusion (I/R) injury. Induction of oxidative …