Palmitoleate attenuates palmitate-induced Bim and PUMA up-regulation and hepatocyte lipoapoptosis
Y Akazawa, S Cazanave, JL Mott, N Elmi, SF Bronk… - Journal of …, 2010 - Elsevier
BACKGROUND & AIMS: Saturated free fatty acids induce hepatocyte lipoapoptosis. This
lipotoxicity involves an endoplasmic reticulum stress response, activation of JNK, and
altered expression and function of Bcl-2 proteins. The mono-unsaturated free fatty acid,
palmitoleate is an adipose-derived lipokine, which suppresses free fatty acid-mediated
lipotoxicity by unclear mechanisms. Herein we examined the mechanisms responsible for
cytoprotection. METHODS: We employed isolated human and mouse primary hepatocytes …
lipotoxicity involves an endoplasmic reticulum stress response, activation of JNK, and
altered expression and function of Bcl-2 proteins. The mono-unsaturated free fatty acid,
palmitoleate is an adipose-derived lipokine, which suppresses free fatty acid-mediated
lipotoxicity by unclear mechanisms. Herein we examined the mechanisms responsible for
cytoprotection. METHODS: We employed isolated human and mouse primary hepatocytes …
