[HTML][HTML] A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language?
cell, 2011•cell.com
Here, we present a unifying hypothesis about how messenger RNAs, transcribed
pseudogenes, and long noncoding RNAs" talk" to each other using microRNA response
elements (MREs) as letters of a new language. We propose that this" competing
endogenous RNA"(ceRNA) activity forms a large-scale regulatory network across the
transcriptome, greatly expanding the functional genetic information in the human genome
and playing important roles in pathological conditions, such as cancer.
pseudogenes, and long noncoding RNAs" talk" to each other using microRNA response
elements (MREs) as letters of a new language. We propose that this" competing
endogenous RNA"(ceRNA) activity forms a large-scale regulatory network across the
transcriptome, greatly expanding the functional genetic information in the human genome
and playing important roles in pathological conditions, such as cancer.
Here, we present a unifying hypothesis about how messenger RNAs, transcribed pseudogenes, and long noncoding RNAs "talk" to each other using microRNA response elements (MREs) as letters of a new language. We propose that this "competing endogenous RNA" (ceRNA) activity forms a large-scale regulatory network across the transcriptome, greatly expanding the functional genetic information in the human genome and playing important roles in pathological conditions, such as cancer.
cell.com