Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease
Nature genetics, 2009•nature.com
We identify the SLC22A3-LPAL2-LPA gene cluster as a strong susceptibility locus for
coronary artery disease (CAD) through a genome-wide haplotype association (GWHA)
study. This locus was not identified from previous genome-wide association (GWA) studies
focused on univariate analyses of SNPs. The proposed approach may have wide utility for
analyzing GWA data for other complex traits.
coronary artery disease (CAD) through a genome-wide haplotype association (GWHA)
study. This locus was not identified from previous genome-wide association (GWA) studies
focused on univariate analyses of SNPs. The proposed approach may have wide utility for
analyzing GWA data for other complex traits.
Abstract
We identify the SLC22A3-LPAL2-LPA gene cluster as a strong susceptibility locus for coronary artery disease (CAD) through a genome-wide haplotype association (GWHA) study. This locus was not identified from previous genome-wide association (GWA) studies focused on univariate analyses of SNPs. The proposed approach may have wide utility for analyzing GWA data for other complex traits.
nature.com
