From the molecular biology of prolactin and its receptor to the lessons learned from knockout mice models
V Goffin, N Binart, P Clément-Lacroix… - Genetic analysis …, 1999 - Elsevier
Prolactin (PRL), a polypeptide hormone secreted mainly by the pituitary and, to a lesser
extent, by peripheral tissues, affects more physiological processes than all other pituitary
hormones combined since it is involved in> 300 separate functions in vertebrates. Its main
actions are related to lactation and reproduction. The initial step of PRL action is the binding
to a specific membrane receptor, the PRLR, which belongs to the class 1 cytokine receptor
superfamily. PRL-binding sites have been identified in a number of tissues and cell types in …
extent, by peripheral tissues, affects more physiological processes than all other pituitary
hormones combined since it is involved in> 300 separate functions in vertebrates. Its main
actions are related to lactation and reproduction. The initial step of PRL action is the binding
to a specific membrane receptor, the PRLR, which belongs to the class 1 cytokine receptor
superfamily. PRL-binding sites have been identified in a number of tissues and cell types in …
