Inverse temporal changes of lipoxin A4 and leukotrienes in children with Henoch–Schönlein purpura

SH Wu, PY Liao, PL Yin, YM Zhang, L Dong - … , Leukotrienes and essential …, 2009 - Elsevier
The pathogenesis of Henoch–Schönlein purpura (HSP) is not clearly understood. It remains
unclear how changes of lipoxin A4 (LXA4) that acts as a “braking signal” in inflammatory
process occur in patients with HSP. In this study, we determined the temporal changes of
blood and urinary LXA4, Leukotriene (LT) B4 and urinary LTE4 in 49 children with HSP.
Inverse temporal changes between gradually increased blood and urinary LXA4 and
gradually decreased blood and urinary LTB4 and urinary LTE4 were found in patients with …