Bone marrow–derived myofibroblasts contribute to the renal interstitial myofibroblast population and produce procollagen I after ischemia/reperfusion in rats
M Broekema, MC Harmsen, MJA van Luyn… - Journal of the …, 2007 - journals.lww.com
Bone marrow–derived cells (BMDC) have been proposed to exert beneficial effects after
renal ischemia/reperfusion injury (IRI) by engraftment in the tubular epithelium. However,
BMDC can give rise to myofibroblasts and may contribute to fibrosis. BMDC contribution to
the renal interstitial myofibroblast population in relation to fibrotic changes after IRI in rats
was investigated. A model of unilateral renal IRI (45 min of ischemia) was used in F344 rats
that were reconstituted with R26-human placental alkaline phosphatase transgenic BM to …
renal ischemia/reperfusion injury (IRI) by engraftment in the tubular epithelium. However,
BMDC can give rise to myofibroblasts and may contribute to fibrosis. BMDC contribution to
the renal interstitial myofibroblast population in relation to fibrotic changes after IRI in rats
was investigated. A model of unilateral renal IRI (45 min of ischemia) was used in F344 rats
that were reconstituted with R26-human placental alkaline phosphatase transgenic BM to …
