The immunoregulatory role of CD1d-restricted natural killer T cells in disease
HJJ Van Der Vliet, JW Molling, BME Von Blomberg… - Clinical …, 2004 - Elsevier
Natural killer T (NKT) cells constitute a T cell subpopulation that shares several
characteristics with NK cells. NKT cells are characterized by a narrow T cell antigen receptor
(TCR) repertoire, recognize glycolipid antigen in the context of the monomorphic CD1d
antigen-presenting molecule, and have the unique capacity to rapidly produce large
amounts of both T helper (Th) 1 and Th2 cytokines. Important roles of NKT cells have now
been demonstrated in the regulation of autoimmune, allergic, antimicrobial, and antitumor …
characteristics with NK cells. NKT cells are characterized by a narrow T cell antigen receptor
(TCR) repertoire, recognize glycolipid antigen in the context of the monomorphic CD1d
antigen-presenting molecule, and have the unique capacity to rapidly produce large
amounts of both T helper (Th) 1 and Th2 cytokines. Important roles of NKT cells have now
been demonstrated in the regulation of autoimmune, allergic, antimicrobial, and antitumor …
