[HTML][HTML] RGD-independent binding of integrin α9β1 to the ADAM-12 and-15 disintegrin domains mediates cell-cell interaction
K Eto, W Puzon-McLaughlin, D Sheppard… - Journal of Biological …, 2000 - ASBMB
ADAMs (adisintegrinand metalloproteases) mediate several important processes (eg tumor
necrosis factor-α release, fertilization, and myoblast fusion). The ADAM disintegrin domains
generally lack RGD motifs, and their receptors are virtually unknown. Here we show that
integrin α 9 β 1 specifically interacts with the recombinant ADAMs-12 and-15 disintegrin
domains in an RGD-independent manner. We also show that interaction between ADAM-12
or-15 and α 9 β 1 supports cell-cell interaction. Interestingly, the cation requirement and …
necrosis factor-α release, fertilization, and myoblast fusion). The ADAM disintegrin domains
generally lack RGD motifs, and their receptors are virtually unknown. Here we show that
integrin α 9 β 1 specifically interacts with the recombinant ADAMs-12 and-15 disintegrin
domains in an RGD-independent manner. We also show that interaction between ADAM-12
or-15 and α 9 β 1 supports cell-cell interaction. Interestingly, the cation requirement and …
