[HTML][HTML] Platelet activation by dimeric β2‐glycoprotein I requires signaling via both glycoprotein Ibα and apolipoprotein E receptor 2′
RT Urbanus, MTT Pennings, R Derksen… - Journal of Thrombosis …, 2008 - Elsevier
Background: Dimerization of β 2‐glycoprotein I (β 2‐GPI) by autoantibodies is thought to
trigger the clinical manifestations observed in the antiphospholipid syndrome. Arterial
thrombosis, a frequently occurring clinical manifestation of the antiphospholipid syndrome, is
a process in which platelets play a crucial role. Previous work has shown that binding of
dimeric β 2‐GPI to the platelet receptors apolipoprotein E receptor 2′(ApoER2′) and
glycoprotein Ibα (GPIbα) mediates increased platelet activation in an in vitro thrombosis …
trigger the clinical manifestations observed in the antiphospholipid syndrome. Arterial
thrombosis, a frequently occurring clinical manifestation of the antiphospholipid syndrome, is
a process in which platelets play a crucial role. Previous work has shown that binding of
dimeric β 2‐GPI to the platelet receptors apolipoprotein E receptor 2′(ApoER2′) and
glycoprotein Ibα (GPIbα) mediates increased platelet activation in an in vitro thrombosis …
