[HTML][HTML] Poly (ADP-ribose) polymerase 1 interacts with nuclear respiratory factor 1 (NRF-1) and plays a role in NRF-1 transcriptional regulation
MB Hossain, P Ji, R Anish, RH Jacobson… - Journal of biological …, 2009 - ASBMB
Nuclear respiratory factor 1 (NRF-1) is one of the key transcriptional activators for nuclear-
coded genes involved in mitochondrial biogenesis and function as well as for many
housekeeping genes. A transcriptional co-activator PGC-1 and its related family member
PRC have previously been shown to interact with NRF-1 and co-activate NRF-1. We show
here that NRF-1 can also directly interact with poly (ADP-ribose) polymerase 1 (PARP-1)
and co-purify the PARP-1· DNA-PK· Ku80· Ku70· topoisomerase IIβ-containing protein …
coded genes involved in mitochondrial biogenesis and function as well as for many
housekeeping genes. A transcriptional co-activator PGC-1 and its related family member
PRC have previously been shown to interact with NRF-1 and co-activate NRF-1. We show
here that NRF-1 can also directly interact with poly (ADP-ribose) polymerase 1 (PARP-1)
and co-purify the PARP-1· DNA-PK· Ku80· Ku70· topoisomerase IIβ-containing protein …