[HTML][HTML] DNA-dependent protein kinase-independent activation of p53 in response to DNA damage
S Burma, A Kurimasa, G Xie, Y Taya, R Araki… - Journal of Biological …, 1999 - ASBMB
Phosphorylation at serine 15 of the human p53 tumor suppressor protein is induced by DNA
damage and correlates with accumulation of p53 and its activation as a transcription factor.
The DNA-dependent protein kinase (DNA-PK) can phosphorylate serine 15 of human p53
and the homologous serine 18 of murine p53in vitro. Contradictory reports exist about the
requirement for DNA-PK in vivo for p53 activation and cell cycle arrest in response to
ionizing radiation. While primary SCID (severe combined immunodeficiency) cells, that have …
damage and correlates with accumulation of p53 and its activation as a transcription factor.
The DNA-dependent protein kinase (DNA-PK) can phosphorylate serine 15 of human p53
and the homologous serine 18 of murine p53in vitro. Contradictory reports exist about the
requirement for DNA-PK in vivo for p53 activation and cell cycle arrest in response to
ionizing radiation. While primary SCID (severe combined immunodeficiency) cells, that have …