Distinct roles for basal and induced COX-2 in podocyte injury
H Cheng, X Fan, Y Guan, GW Moeckel… - Journal of the …, 2009 - journals.lww.com
Transgenic mice that overexpress cyclooxygenase-2 (COX-2) selectively in podocytes are
more susceptible to glomerular injury by adriamycin and puromycin (PAN). To investigate
the potential roles of COX-2 metabolites, we studied mice with selective deletion of
prostanoid receptors and generated conditionally immortalized podocyte lines from mice
with either COX-2 deletion or overexpression. Podocytes that overexpressed COX-2 were
virtually indistinguishable from wild-type podocytes but were significantly more sensitive to …
more susceptible to glomerular injury by adriamycin and puromycin (PAN). To investigate
the potential roles of COX-2 metabolites, we studied mice with selective deletion of
prostanoid receptors and generated conditionally immortalized podocyte lines from mice
with either COX-2 deletion or overexpression. Podocytes that overexpressed COX-2 were
virtually indistinguishable from wild-type podocytes but were significantly more sensitive to …