[HTML][HTML] Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum …
K Ma, KM Vattem, RC Wek - Journal of Biological Chemistry, 2002 - ASBMB
Phosphorylation of eukaryotic initiation factor-2 (eIF2) by pancreatic eIF2 kinase (PEK),
induces a program of translational expression in response to accumulation of malfolded
protein in the endoplasmic reticulum (ER). This study addresses the mechanisms activating
PEK, also designated PERK or EIF2AK3. We describe the characterization of two regions in
the ER luminal portion of the transmembrane PEK that carry out distinct functions in the
regulation of this eIF2 kinase. The first region mediates oligomerization between PEK …
induces a program of translational expression in response to accumulation of malfolded
protein in the endoplasmic reticulum (ER). This study addresses the mechanisms activating
PEK, also designated PERK or EIF2AK3. We describe the characterization of two regions in
the ER luminal portion of the transmembrane PEK that carry out distinct functions in the
regulation of this eIF2 kinase. The first region mediates oligomerization between PEK …