[HTML][HTML] AMP-activated protein kinase is activated as a consequence of lipolysis in the adipocyte: potential mechanism and physiological relevance
MS Gauthier, H Miyoshi, SC Souza… - Journal of biological …, 2008 - ASBMB
AMP-activated protein kinase (AMPK) is activated in adipocytes during exercise and other
states in which lipolysis is stimulated. However, the mechanism (s) responsible for this effect
and its physiological relevance are unclear. To examine these questions, 3T3-L1 adipocytes
were treated with cAMP-inducing agents (isoproterenol, forskolin, and
isobutylmethylxanthine), which stimulate lipolysis and activate AMPK. When lipolysis was
partially inhibited with the general lipase inhibitor orlistat, AMPK activation by these agents …
states in which lipolysis is stimulated. However, the mechanism (s) responsible for this effect
and its physiological relevance are unclear. To examine these questions, 3T3-L1 adipocytes
were treated with cAMP-inducing agents (isoproterenol, forskolin, and
isobutylmethylxanthine), which stimulate lipolysis and activate AMPK. When lipolysis was
partially inhibited with the general lipase inhibitor orlistat, AMPK activation by these agents …