[HTML][HTML] Ligand specificity of the anaphylatoxin C5L2 receptor and its regulation on myeloid and epithelial cell lines
K Johswich, M Martin, J Thalmann… - Journal of Biological …, 2006 - ASBMB
During complement activation the pro-inflammatory anaphylatoxins C3a and C5a are
generated, which interact with the C3a receptor and C5a receptor (CD88), respectively. C5a
and its degradation product C5a-des-Arg 74 also bind to the C5a receptor-like 2 (C5L2).
C3a and C3a-des-Arg 77, also called acylation-stimulating protein, augment triglyceride
synthesis and glucose uptake in adipocytes and skin fibroblasts. Based on data obtained
using transfected HEK293 and RBL cells, C5L2 is additionally proposed as a functional …
generated, which interact with the C3a receptor and C5a receptor (CD88), respectively. C5a
and its degradation product C5a-des-Arg 74 also bind to the C5a receptor-like 2 (C5L2).
C3a and C3a-des-Arg 77, also called acylation-stimulating protein, augment triglyceride
synthesis and glucose uptake in adipocytes and skin fibroblasts. Based on data obtained
using transfected HEK293 and RBL cells, C5L2 is additionally proposed as a functional …
