Anti-CD53 monoclonal antibody induced LFA-1/ICAM-1-dependent and-independent lymphocyte homotypic cell aggregation
L Cao, T Yoshino, N Kawasaki, I Sakuma, K Takahashi… - Immunobiology, 1997 - Elsevier
CD53 is a pan-leukocyte glycoprotein and belongs to a member of the tetraspan family of
cell membrane proteins. The predicted structure and functional characteristics of CD53
suggest that it may play important roles in transmembrane signaling, but its roles in cell
adhesion have not been clarified. The present study shows that anti-CD53 monoclonal
antibody (mAb), HI29 induced homotypic cell aggregation of lymphoid cell lines including a
B cell line from a patient with leukocyte adhesion deficiency syndrome (LAD). The homotypic …
cell membrane proteins. The predicted structure and functional characteristics of CD53
suggest that it may play important roles in transmembrane signaling, but its roles in cell
adhesion have not been clarified. The present study shows that anti-CD53 monoclonal
antibody (mAb), HI29 induced homotypic cell aggregation of lymphoid cell lines including a
B cell line from a patient with leukocyte adhesion deficiency syndrome (LAD). The homotypic …
