[HTML][HTML] Angiopoietin-like protein 4 is a potent hyperlipidemia-inducing factor in mice and inhibitor of lipoprotein lipase
K Yoshida, T Shimizugawa, M Ono, H Furukawa - Journal of lipid research, 2002 - ASBMB
Studies with KK/San, obese and diabetic model mice having a unique hypotriglyceridemia
phenotype, revealed that angiopoietin-like protein 3 (ANGPTL3) regulates lipid metabolism
in mice. To determine the lipid-modulating role of other ANGPTLs, we focused on ANGPTL4,
which overall shows a significant similarity to ANGPTL3. Surprisingly, an intravenous
injection of the ANGPTL4 protein in KK/San mice rapidly increased the circulating plasma
lipid levels at a higher rate than ANGPTL3 protein. Furthermore, the ANGPTL4 protein …
phenotype, revealed that angiopoietin-like protein 3 (ANGPTL3) regulates lipid metabolism
in mice. To determine the lipid-modulating role of other ANGPTLs, we focused on ANGPTL4,
which overall shows a significant similarity to ANGPTL3. Surprisingly, an intravenous
injection of the ANGPTL4 protein in KK/San mice rapidly increased the circulating plasma
lipid levels at a higher rate than ANGPTL3 protein. Furthermore, the ANGPTL4 protein …