[HTML][HTML] HIP1 and HIP1r Stabilize Receptor Tyrosine Kinases and Bind 3-Phosphoinositides via Epsin N-terminal Homology Domains*[boxs]
TS Hyun, DS Rao, D Saint-Dic, LE Michael… - Journal of Biological …, 2004 - ASBMB
Huntingtin-interacting protein 1-related (HIP1r) is the only known mammalian relative of
huntingtin-interacting protein 1 (HIP1), a protein that transforms fibroblasts via undefined
mechanisms. Here we demonstrate that both HIP1r and HIP1 bind inositol lipids via their
epsin N-terminal homology (ENTH) domains. In contrast to other ENTH domain-containing
proteins, lipid binding is preferential to the 3-phosphate-containing inositol lipids,
phosphatidylinositol 3, 4-bisphosphate and phosphatidylinositol 3, 5-bisphosphate …
huntingtin-interacting protein 1 (HIP1), a protein that transforms fibroblasts via undefined
mechanisms. Here we demonstrate that both HIP1r and HIP1 bind inositol lipids via their
epsin N-terminal homology (ENTH) domains. In contrast to other ENTH domain-containing
proteins, lipid binding is preferential to the 3-phosphate-containing inositol lipids,
phosphatidylinositol 3, 4-bisphosphate and phosphatidylinositol 3, 5-bisphosphate …
