[HTML][HTML] Neuronal differentiation of bone marrow-derived stromal stem cells involves suppression of discordant phenotypes through gene silencing

H Egusa, FE Schweizer, CC Wang, Y Matsuka… - Journal of Biological …, 2005 - ASBMB
Tissue engineering involves the construction of transplantable tissues in which bone marrow
aspirates may serve as an accessible source of autogenous multipotential mesenchymal
stem cells. Increasing reports indicate that the lineage restriction of adult mesenchymal stem
cells may be less established than previously believed, and stem cell-based therapeutics
await the establishment of an efficient protocol capable of achieving a prescribed phenotype
differentiation. We have investigated how adult mouse bone marrow-derived stromal cells …