Anti-inflammatory and upper gastrointestinal effects of celecoxib in rheumatoid arthritis: a randomized controlled trial
LS Simon, AL Weaver, DY Graham, AJ Kivitz… - Jama, 1999 - jamanetwork.com
ContextIn vitro studies have shown that celecoxib inhibits cyclooxygenase 2 (COX-2) but not
COX-1, suggesting that this drug may have anti-inflammatory and analgesic activity without
adverse upper gastrointestinal (GI) tract effects that result from COX-1 inhibition. ObjectiveTo
test whether celecoxib has efficacy as an anti-inflammatory and analgesic with reduced GI
tract mucosal damage compared with conventional nonsteroidal anti-inflammatory drugs in
patients with rheumatoid arthritis. DesignRandomized, multicenter, placebo-controlled …
COX-1, suggesting that this drug may have anti-inflammatory and analgesic activity without
adverse upper gastrointestinal (GI) tract effects that result from COX-1 inhibition. ObjectiveTo
test whether celecoxib has efficacy as an anti-inflammatory and analgesic with reduced GI
tract mucosal damage compared with conventional nonsteroidal anti-inflammatory drugs in
patients with rheumatoid arthritis. DesignRandomized, multicenter, placebo-controlled …
