[HTML][HTML] Fluid shear stress stimulates big mitogen-activated protein kinase 1 (BMK1) activity in endothelial cells: dependence on tyrosine kinases and intracellular …
C Yan, M Takahashi, M Okuda, JD Lee… - Journal of Biological …, 1999 - ASBMB
Mitogen-activated protein (MAP) kinases including ERK1/2 and JNK play an important role
in shear stress-mediated gene expression in endothelial cells (EC). A new MAP kinase
termed big MAP kinase 1 (BMK1/ERK5) has been shown to phosphorylate and activate the
transcription factor MEF2C, which is highly expressed in EC. To determine the effects of
shear stress on BMK1, bovine aortic EC were exposed to steady laminar flow (shear stress=
12 dynes/cm 2). Flow activated BMK1 within 10 min with peak activation at 60 min (7.1±0.6 …
in shear stress-mediated gene expression in endothelial cells (EC). A new MAP kinase
termed big MAP kinase 1 (BMK1/ERK5) has been shown to phosphorylate and activate the
transcription factor MEF2C, which is highly expressed in EC. To determine the effects of
shear stress on BMK1, bovine aortic EC were exposed to steady laminar flow (shear stress=
12 dynes/cm 2). Flow activated BMK1 within 10 min with peak activation at 60 min (7.1±0.6 …
