Nitrate tolerance and the links with endothelial dysfunction and oxidative stress
KE Fayers, MH Cummings, KM Shaw… - British journal of …, 2003 - Wiley Online Library
KE Fayers, MH Cummings, KM Shaw, DW Laight
British journal of clinical pharmacology, 2003•Wiley Online LibraryIdentification of nitric oxide as the molecule responsible for endothelial dependant
vasodilatation has led to an explosion of interest in endothelial function. Oxidative stress has
been identified as an important factor in the development of tolerance to organic nitrates.
This review examines the evidence supporting this recently developed theory and how
mechanisms of nitrate tolerance may link with the wider picture of primary nitric oxide
resistance.
vasodilatation has led to an explosion of interest in endothelial function. Oxidative stress has
been identified as an important factor in the development of tolerance to organic nitrates.
This review examines the evidence supporting this recently developed theory and how
mechanisms of nitrate tolerance may link with the wider picture of primary nitric oxide
resistance.
Identification of nitric oxide as the molecule responsible for endothelial dependant vasodilatation has led to an explosion of interest in endothelial function. Oxidative stress has been identified as an important factor in the development of tolerance to organic nitrates. This review examines the evidence supporting this recently developed theory and how mechanisms of nitrate tolerance may link with the wider picture of primary nitric oxide resistance.
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