Involvement of IRAK-M in peptidoglycan-induced tolerance in macrophages
K Nakayama, S Okugawa, S Yanagimoto… - Journal of Biological …, 2004 - ASBMB
The molecular mechanisms by which pathogen-associated molecular patterns recognized
by TLR2, such as peptidoglycan (PGN), induce homotolerance are largely unknown. It was
recently reported that IRAK-M negatively regulates TLR signaling. In this study, we elucidate
the molecular mechanisms of tolerance induced by PGN, with a focus on the role of IRAK-M.
We demonstrate that pretreatment of macrophage RAW264. 7 cells with a high
concentration (30 μg/ml) of PGN for 16 h effectively induces tolerance against following …
by TLR2, such as peptidoglycan (PGN), induce homotolerance are largely unknown. It was
recently reported that IRAK-M negatively regulates TLR signaling. In this study, we elucidate
the molecular mechanisms of tolerance induced by PGN, with a focus on the role of IRAK-M.
We demonstrate that pretreatment of macrophage RAW264. 7 cells with a high
concentration (30 μg/ml) of PGN for 16 h effectively induces tolerance against following …
