Ser1928 is a common site for Cav1. 2 phosphorylation by protein kinase C isoforms
L Yang, G Liu, SI Zakharov, JP Morrow… - Journal of Biological …, 2005 - ASBMB
Voltage-dependent Ca 2+ channel (Ca v 1.2, L-type Ca 2+ channel) function is highly
regulated by hormones and neurotransmitters in large part through the activation of kinases
and phosphatases. Regulation of Ca v 1.2 by protein kinase C (PKC) is of significant
physiologic importance, mediating, in part, the cardiac response to hormonal regulation.
Although PKC has been reported to mediate activation and/or inhibition of Ca v 1.2 function,
the molecular mechanisms mediating the response have not been definitively elucidated …
regulated by hormones and neurotransmitters in large part through the activation of kinases
and phosphatases. Regulation of Ca v 1.2 by protein kinase C (PKC) is of significant
physiologic importance, mediating, in part, the cardiac response to hormonal regulation.
Although PKC has been reported to mediate activation and/or inhibition of Ca v 1.2 function,
the molecular mechanisms mediating the response have not been definitively elucidated …