Calcium/calmodulin-dependent protein kinase II phosphorylates and regulates the Drosophila eag potassium channel
Z Wang, GF Wilson, LC Griffith - Journal of Biological Chemistry, 2002 - ASBMB
Modulation of neuronal excitability is believed to be an important mechanism of plasticity in
the nervous system. Calcium/calmodulin-dependent protein kinase II (CaMKII) has been
postulated to regulate the ether à go-go (eag) potassium channel in Drosophila. Inhibition of
CaMKII and mutation of the eag gene both cause hyperexcitability at the larval
neuromuscular junction (NMJ) and memory formation defects in the adult. In this study, we
identify a single site, threonine 787, as the major CaMKII phosphorylation site in Eag. This …
the nervous system. Calcium/calmodulin-dependent protein kinase II (CaMKII) has been
postulated to regulate the ether à go-go (eag) potassium channel in Drosophila. Inhibition of
CaMKII and mutation of the eag gene both cause hyperexcitability at the larval
neuromuscular junction (NMJ) and memory formation defects in the adult. In this study, we
identify a single site, threonine 787, as the major CaMKII phosphorylation site in Eag. This …