Cell cycle regulation by the Cdc25 phosphatase family
I Nilsson, I Hoffmann - Progress in cell cycle research, 1998 - Springer
I Nilsson, I Hoffmann
Progress in cell cycle research, 1998•SpringerActivation of cyclin-dependent kinases in higher eukaryotic cells can be achieved through
dephosphorylation by members of the Cdc25 phosphatase family, Cdc25A, Cdc25B and
Cdc25C. Cdc25A plays an important role at the G1/S-phase transition. Cdc25B undergoes
activation during S-phase and plays a role in activating the mitotic kinase Cdkl/cyclin B in the
cytoplasm. Active Cdkl/cyclin B then phosphorylates and activates Cdc25C leading to a
positive feedback mechanism and to entry into mitosis. Cdc25A and B are potential human …
dephosphorylation by members of the Cdc25 phosphatase family, Cdc25A, Cdc25B and
Cdc25C. Cdc25A plays an important role at the G1/S-phase transition. Cdc25B undergoes
activation during S-phase and plays a role in activating the mitotic kinase Cdkl/cyclin B in the
cytoplasm. Active Cdkl/cyclin B then phosphorylates and activates Cdc25C leading to a
positive feedback mechanism and to entry into mitosis. Cdc25A and B are potential human …
Abstract
Activation of cyclin-dependent kinases in higher eukaryotic cells can be achieved through dephosphorylation by members of the Cdc25 phosphatase family, Cdc25A, Cdc25B and Cdc25C. Cdc25A plays an important role at the G1/S-phase transition. Cdc25B undergoes activation during S-phase and plays a role in activating the mitotic kinase Cdkl/cyclin B in the cytoplasm. Active Cdkl/cyclin B then phosphorylates and activates Cdc25C leading to a positive feedback mechanism and to entry into mitosis. Cdc25A and B are potential human oncogenes. In addition, Cdc25 is a main player of the G2 arrest caused by DNA damage or in the presence of unreplicated DNA.
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